منابع مشابه
New tubulins in protozoal parasites
More than 20 years ago, biochemical analysis of the eukaryotic cell cytoskeleton revealed the major component proteins. The heterodimeric (α/β) protein tubulin was defined as the building block of microtubules, assembled in a polar manner into specifically arranged protofilaments in the microtubule wall [1]. The next two members of the tubulin protein superfamily were both discovered by genetic...
متن کاملProfiling the anti-protozoal activity of anti-cancer HDAC inhibitors against Plasmodium and Trypanosoma parasites
Histone deacetylase (HDAC) enzymes work together with histone acetyltransferases (HATs) to reversibly acetylate both histone and non-histone proteins. As a result, these enzymes are involved in regulating chromatin structure and gene expression as well as other important cellular processes. HDACs are validated drug targets for some types of cancer, with four HDAC inhibitors clinically approved....
متن کاملProtozoal Tropical Infections
© 2005 The Medicine Publishing Company Ltd 50 MEDICINE 33:8 Different species of the protozoan Trypanosoma are of similar appearance (Figure 1), and all are termed ‘kinetoplastids’ because they move using a flagellum that obtains energy from a mitochondrion called a plastid. However, trypanosomes also differ in many ways, including aspects of their molecular and cellular biology, their transmis...
متن کاملEquine protozoal myeloencephalitis.
Equine protozoal myeloencephalitis (EPM) can be caused by either of 2 related protozoan parasites, Sarcocystis neurona and Neospora hughesi, although S. neurona is the most frequent etiologic pathogen. Horses are commonly infected, but clinical disease occurs infrequently; the factors influencing disease occurrence are not well understood. Risk factors for the development of EPM include the pre...
متن کاملLoss of infectivity of mycobacterial and protozoal exoplasmic parasites after exposure in vitro to the polyenzymic cocktail 'PIGO'.
A myeloperoxidase-mediated oxygen-dependent antimicrobial system has been discovered by Karnovsky, Klebanoff, Rossi, Sbarra, Schultz and their co-workers as the most powerful among several physiological systems that specifically equip the lysosomes of polymorphonuclear leucocytes and endow them with a considerable capacity to destroy micro-organisms after endocytosis (Klebanoff, 1975). Since th...
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ژورنال
عنوان ژورنال: Proceedings of the Royal Society of Medicine
سال: 1929
ISSN: 0035-9157
DOI: 10.1177/003591572902200645